Table 2. Predose selenium and metabolites by agent and by day or study.
| Treatment Group | |||||
|---|---|---|---|---|---|
| Agent | Placebo | Methyl Selenocysteine | Selenomethionine | ||
| Dose | 400 mcg | 800 mcg | 400 mcg | 800 mcg | |
| N | 3 | 7 | 5 | 5 | 5 |
| Plasma Se concentration (mcg/L) | |||||
| Day 1 | 106 ± 12 | 108 ± 15 | 116 ± 14 | 105 ± 8 | 104 ± 14 |
| Day 28 | 101 ± 7 | 129 ± 231 | 128 ± 13 | 209 ± 361 | 244 ± 431 |
| Day 84 | 95 ± 131 | 123 ± 131 | 120 ± 12 | 230 ± 221 | 291 ± 471 |
| Plasma Selenoprotein P concentration (mg/L) | |||||
| Day 1 | 8.0 ± 12 | 6.9 ± 10 | 7.5 ± 16 | 7.0 ± 12 | 7.5 ± 4 |
| Day 28 | 7.5 ± 6 | 7.6 ± 20 | 8.5 ± 131 | 6.6 ± 15 | 7.9 ± 12 |
| Day 84 | 7.7 ± 17 | 7.3 ± 12 | 7.8 ± 12 | 6.5 ± 12 | 7.7 ± 10 |
| Plasma Glutathione Peroxidase activity (Unit/L) | |||||
| Day 1 | 112 ± 33 | 112 ± 11 | 148 ± 34 | 104 ± 13 | 132 ± 30 |
| Day 28 | 115 ± 35 | 121 ± 16 | 150 ± 20 | 125 ± 17 | 167 ± 52 |
| Day 84 | 113 ± 45 | 122 ± 24 | 185 ± 62 | 121 ± 16 | 154 ± 36 |
| Urine Se /Creatinine ratio (ng Se/mg creatine) | |||||
| Day 1 | 58.4 ± 55 | 30.6 ± 10 | 31.6 ± 9 | 44.0 ± 12 | 27.4 ± 11 |
| Day 28 | 41.3 ± 21 | 81.4 ± 16 | 124 ± 29 | 113 ± 30 | 142 ± 33 |
| Day 84 | 61.9 ± 45 | 90.91 ± 18 | 124 ± 21 | 138 ± 391 | 131 ± 571 |
1Difference from Day 1 p <.05 (paired t test).
* Mean ± SD.