Table 1. Histopathology and immunohistochemistry of 1205Lu xenografted tumor into nude mice.
| Control | Histamine | Clozapine | JNJ28610244 | |
|---|---|---|---|---|
| H4Ra | 2.0 ± 0.6 | 3.5 ± 0.3 | 2.5 ± 0.3 | 3.5 ± 0.3 |
| Histamine aHDC a | 3.5 ± 0.93.5 ± 0.8 | 3.0 ± 0.62.0 ± 0.3 | 3.0 ± 0.62.0 ± 0.2 | 2.5 ± 0.31.0 ± 0.2* |
| PCNA b | 83.0 ± 9.0 | 35.0 ± 10.0* | 40.0 ± 4.0* | 24.0 ± 7.6*** |
| Mitotic index c | 19.0 ± 2.0 | 9.0 ± 2.0* | 12.0 ± 3.0* | 10.0 ± 2.0* |
| Vessels d | 19.0 ± 1.0 | 12.0 ± 3.0* | 12.0 ± 2.0* | 10.0 ± 3.0* |
| Neutrophils e | 27.0 ± 9.8 | 7.0 ± 1.5 | 3.4 ± 0.9# | 4.8 ± 2.0# |
| Lymphocytesf | 5.0 ± 1.2 | 7.0 ± 1.9 | 11.0 ± 3.8 | 16.0 ± 3.8# |
a Score of stained cells; b Percentage of positive nuclei; c number of cells with visible chromosomes at 400X magnification in 5 random fields; d number of intratumoral vessels at 200X magnification in 10 random fields (hot spots); e number of neutrophils with visible segmented nucleus at 400X magnification in 5 random fields, f number of lymphocytes at 400X magnification in 5 random fields Results were expressed as mean ± SEM; *P < 0.05, **P < 0.01, ***P < 0.001 vs. Control group; Unpaired t-test. #P < 0.05 vs. Control group; ANOVA Dunnett's Multiple Comparison post-Test.