Table 1. Diagnostic accuracy of anti-MDA5 antibodies for DM/classic DM/CADM in a stratified analysis according to detection method.

Disease type	Method	Pooled sensitivity(95% CI)	Pooled specificity(95% CI)	AUC
DM	ELISA	0.18 (0.14–0.23)	1.00 (0.97–1.00)	0.8589
DM	Immunoprecipitation	0.17 (0.13–0.22)	1.00 (0.96–1.00)	0.8121
Classic DM	ELISA	0.13 (0.08–0.19)	1.00 (0.96–1.00)	0.8167
CADM	ELISA	0.46 (0.38–0.56)	1.00 (0.97–1.00)	0.9301
CADM	Immunoprecipitation	0.62 (0.52–0.70)	1.00 (0.97–1.00)	0.9381

Abbreviations: DM = dermatomyositis; CADM = clinically amyopathic dermatomyositis; ELISA = enzyme-linked immunosorbent assay; CI = confidence interval; AUC = area under the curve of the summary receiver operating characteristic.