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. 2017 Mar 2;8(16):26911–26917. doi: 10.18632/oncotarget.15850

Figure 1. No effect of miR-29a on tumour onset in a pancreatic cancer model.

Figure 1

Ela1-TAg+ mice, on the wildtype, miR-29a heterozygous and miR-29a knockout backgrounds, were monitored for pancreatic cancer detection by MRI every two weeks. (A) Representative MRI scans for wildtype (top) and miR-29a knockout (bottom) mice, at 9 weeks, 15 weeks and 21 weeks. Arrows indicate detected tumours. (B) Cumulative incidence of pancreatic cancer as a function of age at tumour onset in wild-type, heterozygous and miR-29a-decifient mice, for female and (n = 24, 11, 9) (C) male (n = 21, 14, 10). The P values were calculated using the log-rank test. (D) Violin plots showing the mean, standard deviation and kernel probability density of the age at tumour onset under each condition in female (upper panel) and male (lower panel) mice. The P values were calculated using two-sided Mann-Whitney U test.