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. 2017 Mar 6;8(16):26969–26978. doi: 10.18632/oncotarget.15926

Figure 3. hTERT could bind with CDX2 promoter in intestinal metaplasia of gastric in the MKN45 cell line.

Figure 3

(A) The luciferase activity of CDX2 in MKN45 cells, after p65 and p50 was over-expressed (unpaired t-test was used to analyze data, *p < 0.05, **p < 0.01). (B) The expression of CDX2, hTERT and KLF4 was detected using WB, after p65 and p50 were suppressed or the signaling pathway was completely suppressed by Bay11-7085. (C) The association of hTERT with p65 or p50 was measured by Co-IP. (D) The ChIP assay was applied to detect the binding relationship with the CDX2 promoter.