Table 2. Association between B7-H4 and clinicalpathological factors in NSCLC.
Variables | No. of studies | No. of patients | Effects model | OR (95%CI) | p | Heterogeneity | |
---|---|---|---|---|---|---|---|
I2(%) | Ph | ||||||
Gender (male vs female) | 8 | 1,128 | Fixed | 0.94(0.68-1.29) | 0.699 | 0 | 0.65 |
Age (≥60 vs <60, years) | 7 | 576 | Fixed | 0.92(0.65-1.29) | 0.617 | 0 | 0.827 |
Histology (SCC vs ADC) | 7 | 1,034 | Random | 2.35(0.77-2.36) | 0.289 | 60.3 | 0.019 |
Lymph node metastasis (yes vs no) | 6 | 527 | Fixed | 3.59(2.39-5.38) | <0.001 | 26.5 | 0.235 |
TNM stage (III+IV vs I+II) | 4 | 830 | Random | 2.36(1.2-4.67) | 0.013 | 54.6 | 0.086 |
Differentiation (poor vs moderate/well) | 4 | 347 | Fixed | 2.11(1.12-3.99) | 0.021 | 0 | 0.583 |
Abbreviations: SCC: Squamous cell carcinoma; ADC: Adenocarcinoma