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. 2017 Mar 6;8(16):27300–27313. doi: 10.18632/oncotarget.15934

Figure 4. ICG-001 inhibits tumor growth in vivo.

Figure 4

ICG-001 treated pedHGG cells show diminished potential to form solid tumors on chorioallantoic membranes (CAM) in vivo and impaired proliferation as indicated by reduced cell-divisions in vitro. (A-B) PedHGG cell lines were pre-incubated with ICG-001 for 48 h; subsequently, equal cell numbers were placed on top of a CAM in an ECM-plaque and tumor growth was assessed by (B) brightfield images and (A) quantification of the grown tumor area. (C) Flow cytometric analysis of cell division by CFSE dilution reveals reduced proliferation following 24 h ICG-001 treatment of glioma cell lines that divided less efficiently (data are represented as mean of at least three biological replicates +/− SEM; * p < 0.05).