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. 2017 Feb 17;8(16):27314–27327. doi: 10.18632/oncotarget.15432

Figure 2. All-trans-retinoic acid (ATRA) and arsenic trioxide (ATO) promote release of HMGB1 and cytokine release in human myeloid cells.

Figure 2

A. HL-60 and NB4 cells were treated with either ATRA (1 μM) or ATO (5 mM) for 24-72 h or ATRA plus ATO for 48 h and the amount of HMGB1 released into the supernatant was analyzed by ELISA. (n=3, *P<0.05 versus untreated group; #P<0.05 versus ATRA or HMGB1 group). B. HL-60 and NB4 cells were treated with ATRA (1 μM) or/and ATO (5 mM) for 48 h and the levels of TNF-α and IL-1β released into the supernatant were analyzed by ELISA. (n=3, *P<0.05 versus untreated group; #P<0.05 versus ATRA or HMGB1 group).