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. 2017 Mar 16;8(16):27454–27470. doi: 10.18632/oncotarget.16247

Figure 3. Co-029 increases the association of EGFR with the tetraspanin web.

Figure 3

(A) Co-029, CD9 and EGFR flow cytometry profiles of Isreco1 cells and Co-029 transduced cell line Is1-Co029. Mean fluorescence intensity (M.F.I.) values are indicated. Background represents the signal detected with a negative control mAb. The level of EGFR is similar in the two cell lines. (B) The presence of Co-029 increases the association of EGFR with the tetraspanin web as shown by the clear co-precipitation of EGFR with CD9 and Co-029 in Is1-Co029 cells whereas only a weak co-precipitation with CD9 is seen in Isreco1 cells. (C) Immunoprecipitation of EGFR by mAb 108 shows the reciprocal association of Co-029 with EGFR.