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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: Shock. 2017 Jun;47(6):726–734. doi: 10.1097/SHK.0000000000000799

Figure 3. Late intervention with antibiotics and fluid resuscitation rescues the majority of mice from otherwise lethal sepsis.

Figure 3

All animals were given a lethal dose of cecal slurry (CS). Mice received antibiotic treatment alone (imipenem, IPM; 1.5mg i.p.), fluid resuscitation alone (1mL physiological saline, s.c.), or a combination treatment of antibiotics and fluid resuscitation (n=5-9 per group) beginning 12 or 24 hours after CS injection. Therapeutic treatment was continued twice daily for five days. (A, D) Survival and (B, E) body temperature were monitored for multiple days. Data is represented as mean ± standard deviation. (C, F) Circulating bacteria load was assessed in the combination treatment groups by culturing blood obtained by micropuncture of the tail vein immediately before the first therapeutic treatment (12, 24h), after 3 treatments (48, 72h) and after 7 treatments (96, 108h). Symbols * and *** represent p<0.05 and p<0.001 respectively compared to no intervention group; † and †† represent p<0.05 and p<0.01 respectively compared to bacteria load before intervention (i.e. 12 and 24h).