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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: Shock. 2017 Jun;47(6):726–734. doi: 10.1097/SHK.0000000000000799

Figure 5. Early, but not late, therapeutic intervention prevents sepsis-induced lung injury.

Figure 5

Mice received either cecal slurry (CS; n=14) or vehicle (10% glycerol; n=4) injection (i.p.). CS-injected mice were divided among the following groups: nonresuscitated, 1h antibiotics, 6h antibiotics, or 12h combination treatment with antibiotics and fluid resuscitation (n=3-4 per group). All animals were euthanized 24 hours after CS or vehicle injection. (A-E) Lung tissue sections stained with H&E. Representative images (400X, scale bar represents 50 μm) are shown for each group. (F) Hisopathological scoring (n=3-4 per group). *** represents p<0.001.