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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Pharmacogenomics J. 2016 Nov 15;18(1):35–42. doi: 10.1038/tpj.2016.75

Table 1.

Univariate and multivariate analysis results for log SN-38 AUC1

Univariate Multivariate3
rsid Gene Function Ref>Alt Estimate SE P Estimate SE P
rs127200662 ABCB1 intronic A>C −0.204 0.070 0.005 −0.217 0.061 6.24 × 10−4
rs6498588 ABCC1 5′-gene A>T 0.111 0.042 0.010 0.123 0.036 9.50 × 10−4
rs356212 ABCC1 intronic C>T 0.191 0.083 0.025
rs2373586 ABCB1 intronic A>C 0.086 0.040 0.033
rs8187843 ABCC1 intronic G>A −0.160 0.084 0.061
rs37435272 ABCC1 3′-UTR C>T 0.113 0.062 0.071
rs2150952 ABCC1 intronic G>A 0.118 0.073 0.109
rs212082 ABCC1 intronic A>G −0.080 0.054 0.142
rs10929302 UGT1A1 promoter G>A 0.145 0.042 0.001 0.154 0.037 9.00 × 10−5
1

SN-38 AUC expressed in units of ng*hr/mL; adjusted for irinotecan dose

2

Homozygous alternate genotypes grouped with heterozygous genotypes

3

R2 = 0.345