Table 1. Participant demographics, clinical and neuropathologic characteristics.
| Asymptomatic AD (n=68) | Symptomatic AD (n=521) | p-value from Chi-square testg | |
|---|---|---|---|
| Age at death | 0.41 | ||
| <60 | 0 (0%) | 8 (1%) | |
| 60-69 | 3 (4%) | 53 (10%) | |
| 70-79 | 14 (21%) | 99 (19%) | |
| 80-89 | 27 (40%) | 217 (42%) | |
| 90+ | 24 (35%) | 144 (28%) | |
| Sex | 0.11 | ||
| Female | 30 (44%) | 287 (55%) | |
| Male | 38 (56%) | 234 (45%) | |
| Educationa | 0.20 | ||
| No college | 13 (19%) | 149 (29%) | |
| 1 - 4 years of college | 31 (46%) | 221 (43%) | |
| At least some graduate school | 24 (35%) | 145 (28%) | |
| APOE | <0.0001 | ||
| Non-carrier (0 ε4 alleles) | 52 (76%) | 245 (47%) | |
| Heterozygous (1 ε4 allele) | 16 (24%) | 226 (43%) | |
| Homozygous (2 ε4 alleles) | 0 (0%) | 50 (10%) | |
| Braak stage | <0.0001 | ||
| 0 | 1 (1%) | 4 (1%) | |
| I-II | 34 (50%) | 44 (8%) | |
| III-IV | 27 (40%) | 126 (24%) | |
| V-VI | 6 (9%) | 347 (67%) | |
| CERAD neuritic plaque frequency | <0.0001 | ||
| None | 12 (18%) | 16 (3%) | |
| Sparse | 24 (35%) | 69 (13%) | |
| Moderate | 18 (26%) | 134 (26%) | |
| Frequent | 14 (21%) | 302 (58%) | |
| Diffuse plaque frequencyb | <0.0001 | ||
| None | 1 (2%) | 10 (2%) | |
| Sparse | 23 (41%) | 61 (13%) | |
| Moderate | 13 (23%) | 91 (19%) | |
| Frequent | 19 (34%) | 318 (66%) | |
| Infarcts or lacunesc | 0.91 | ||
| Not Present | 50 (74%) | 390 (75%) | |
| Present | 18 (26%) | 130 (25%) | |
| Hemorrhorages and microbleeds | >0.999 | ||
| Not Present | 64 (94%) | 490 (94%) | |
| Present | 4 (6%) | 31 (6%) | |
| Arteriosclerosisd | 0.04 | ||
| None | 8 (14%) | 66 (15%) | |
| Mild | 31 (55%) | 165 (37%) | |
| Moderate | 14 (25%) | 141 (31%) | |
| Severe | 3 (6%) | 79 (17%) | |
| Lewy body pathologye | 0.002 | ||
| Not Present | 63 (93%) | 385 (75%) | |
| Present | 5 (7%) | 131 (25%) | |
| Cerebral amyloid angiopathyf | 0.0003 | ||
| Not Present | 56 (85%) | 312 (61%) | |
| Present | 10 (15%) | 196 (39%) |
a
6 symptomatic participants missing information on years of education
b
12 asymptomatic and 41 symptomatic participants were missing information on diffuse plaque frequency
c
1 symptomatic participant was missing information on infarcts and lacunes
d
12 asymptomatic and 70 symptomatic participants were missing information on arteriosclerosis
e
5 symptomatic participants were missing information on Lewy body pathology
f
2 asymptomatic and 13 symptomatic participants were missing information on cerebral amyloid angiopathy
g
Fisher's Exact test performed for age at death, APOE ε4, Braak stage, diffuse plaques, hemorrhages and microbleeds, and arteriosclerosis