. Author manuscript; available in PMC: 2018 Jul 1.

Published in final edited form as: Alzheimer Dis Assoc Disord. 2017 Jul-Sep;31(3):232–238. doi: 10.1097/WAD.0000000000000179

Table 3. Genetic risk score for SNP association with symptomatic AD, adjusted for age at death and sex.

	19 SNPs with <10% missing data^a			21 SNPs with <15% missing data^b			All 22 SNPs

	n	OR	95% CI	n	OR	95% CI	n	OR	95% CI
All participants	419	2.61	(1.61,4.36)	300	2.15	(1.24,3.88)	184	1.87	(1.02,3.60)
APOE ε4 carriers	201	5.01	(1.65,18.54)	143	6.01	(1.20,44.37)	93		NA
APOE ε4 non-carriers	218	2.27	(1.30,4.10)	157	1.97	(1.05,3.84)	91	1.77	(0.87,3.82)

The SNPs associated with BIN1, CLU and MAPT were not included.

The SNP associated with MAPT was not included.

NA= Not applicable; data too sparse for analysis (one cell in the analysis had < 5 entries).

Note: APOE ε4 carriers are those subjects with 1 or 2 ε4 alleles whereas non-carriers contain 0 ε4 alleles. Also note that the ‘n’ for each model is the overall n for both symptomatic and asymptomatic subjects.