Fig. 1.

Effects of sinomenine on the mechanical withdrawal threshold and thermal withdrawal latency in T2DM rats. a The mechanical withdrawal threshold (MWT) was measured. The MWT in T2DM rats treated with sinomenine was higher than that of the T2DM rats (p < 0.01). The upper limit of MWT detection was 26.0 g. Mean ± SEM, n = 10. **p < 0.01 compared with the control group; ^## p < 0.01 compared with the DM group. b The thermal withdrawal latency (TWL) was measured. The TWL in DM rats treated with sinomenine was higher than that of the DM rats (p < 0.01). The upper limit of the thermal withdrawal latency detection was 30 s. Mean ± SEM. n = 10; **p < 0.01 compared with the control group; ^## p < 0.01 compared with the DM group