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KCa1.1 and KCa3.1 may be involved in inflammasome activation. IL-1beta secretion by THP-1 cells under the indicated treatments. NS1619 (25 µM) and Ibtx (50 nM) are KCa1.1 activator and inhibitor respectively. NS309 (10 µM) and clotrimazole (10 µM) are KCa3.1 activator and inhibitor respectively. DMSO was used as vehicle control. One experiment representative of three is shown. *p < 0.05; **p < 0.01; ***p < 0.001.
