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. 2017 May 15;7:1898. doi: 10.1038/s41598-017-01721-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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TRAIL protects against lipid uptake in HepG2 cells. (a) Palmitate increases triglyceride uptake in HepG2 cells over 5 days as measured by Oil red O. (b) Inflammation and (c) fibrotic markers are increased in HepG2 cells in response to palmitate over 5 d. (d) mRNA expression for TRAIL is significantly reduced with lipid uptake over time. (e) DR4 and (f) DR5 expression in response to palmitate. (g) 1 ng/ml TRAIL inhibits palmitate-induced oil red O in HepG2 cells at 24 h compared to the vehicle PBS. Control, untreated cells; n = 3–4/treatment. mRNA expression was normalized to GAPDH. Results are expressed as mean ± SEM; ANOVA; *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001.