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. 2017 May 15;7:1898. doi: 10.1038/s41598-017-01721-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Liver from Trail ^−/− mice exhibit altered glucose and lipid metabolism. (a) Hepatic glucose uptake ex vivo is reduced in baseline 0 w HFD Trail ^−/− vs. wildtype mice (n = 3–5/genotype). mRNA expression for (b) Glucose-6 phosphatase (G6Pase) or GLUT2 mRNA in baseline mice. (c) Insulin-stimulated PEPCK mRNA expression is increased in baseline Trail ^−/− mice (n = 6/genotype). (d) 12 w HFD Trail ^−/− mice exhibit increased PAS staining and have (e) elevated SREBP-1 and (f) HMGCoAR mRNA expression (n = 6/genotype). mRNA expression was normalized to HPRT. Results are expressed as mean ± SEM; Mann-Whitney U-test; *p < 0.05, and ***p < 0.001.