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. 2017 May 15;7:1885. doi: 10.1038/s41598-017-01764-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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GTP-bound state of RAC1 is influenced by the ITGB8 in the endometrial epithelial cells in course of endometrial receptivity. (A) RAC1 activity in terms of a GTP-bound state was analyzed in the isolated and cultured endometrial epithelial cells during various stages of endometrial receptivity period. (B) We also determined the activity of RAC1 in the whole uterus during endometrial receptivity period. (C) At the same time, we assayed the expression and activity of RAC1 in the endometrial epithelial cells after Itgb8 knockdown by its siRNA. (D) With the help of immunoblotting, PCR and densitometry, the expression of RAC1 and activity were determined in the whole uterus/endometrium during the post-receptivity phase in response to Itgb8 knockdown (morpholino oligonucleotides). (***p < 0.001, **p < 0.01,*p < 0.05, NS p > 0.05).