Sr no.	Modified HSV-1	Genetic modification	Transgene inserted	Developmental status
SINGLE GENE DELETIONS
1	dlsptk	TK−	None	Preclinical
2	hrR3	Disruption of large subunit of ribonucleotide reductase and UL39	None	Preclinical
3	HSV1716	ICP34.5−/−	None	clinical trials
4	R3616	ICP34.5−/−	None	Preclinical
5	R4009	Premature stop codon in both copies of ICP34.5	None	Preclinical
MULTIPLE GENES DELETED OHSV-1
6	G207	(a) ICP34.5−/−	None	clinical trials
		(b) Disruption of UL39
7	R7020 (NV1020)	(a) ICP34.5−	None	clinical trials
		(b) TK under control of viral a4 promoter
		(c) UL24−,UL55−,UL56−
8	MGH-1	(a) ICP34.5−/−	None	Preclinical
		(b) Disruption of UL39
9	G47Δ	(a) ICP34.5−/−	None	Preclinical
		(b) Disruption of UL39 gene
		(c) ICP47−
10	Myb34.5	(a) ICP34.5−/−	None	Preclinical
		(b) Disruption of UL39 gene
		(c) Insertion of an ICP34.5 gene under control of the B-myc promoter
11	ΔF3y34.5	(a) ICP34.5−/−	None	Preclinical
		(b) Insertion of an ICP34.5 gene under control of the DF3/MUC1 Promoter
ARMED OHSV-1
12	OncoVexGMCSF	(a) ICP34.5−/−	GMCSF	Approved#
		(b) ICP47−
13	IL-4 HSV	ICP34.5−/−	IL-4	Preclinical
14	IL-10 HSV	ICP34.5−/−	IL10	Preclinical
15	T-mfIL12	(a) ICP34.5−	IL-12	Preclinical
		(b) α47−
		(c) ICP 6 gene inactivation; HSV-1 strain- HSV G47Δ
16	NV1042	; HSV-1 strain- NV1023	IL-12	Preclinical
17	bG47Δ-PF4	(a) ICP34.5−/−	PF4	Preclinical
		(b) Disruption of UL39 gene
		(c) ICP47−.; HSV-1 strain- HSV G47Δ
18	T-TSP-1	(a) ICP34.5−/−	TSP-1	Preclinical
		(b) ICP6−
		(c) α47−
19	RAMBO	(a) ICP34.5−/−	Vstat120	Preclinical
		(b) Possesses a gene disrupting insertion of green fluorescent protein within the viral UL39 locus encoding for ICP6 gene; HSV-1 strain- HSVQ
20	OSVP	(a) OS−	15-PGDH	Preclinical
		(b) vhs; UL41−; HSV-1 strain- OSV
21	HSV1Ycd	(a) ICP6−; HSV-1 strain- bMP6-CMVFcumB	yCD	Preclinical
22	1- vHsv-B7.1-Ig 2- vHsv-IL-12 3- vHsv-IL-18	(a) ICP34.5−/−		Preclinical
		(b) Insertion of Green fluorescent protein gene in ICP locus; HSV-1 strain-vHsv-IL-18	(a) B7.1-Ig (b)IL-12 (c)IL-18
23	G47Δ-IL18/B7	(a) ICP34.5−	IL-18 and soluble B7-1	Preclinical
		(b) α47−
		(c) ICP6−; HSV-1 strain-G47Δ
24	rQT3 and rQLuc	(a) ICP34.5−	TIMP3 or firefly luciferase	Preclinical
		(b) ICP6−; HSV-1 strain- rHSVQ1
	−	(a) ICP34.5−	GALV.fus or EGFP	Preclinical
		(b) fHSV-delta-pac−