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Convertase-directed regulators of complement activation
| Regulator | Regulatory activity | Regulated pathway | Main regulatory compartment | |
|---|---|---|---|---|
| Decay | Cofactor | |||
| CR1 | DAA | CA | CP/LP & AP | Surface |
| DAF | DAA | – | CP/LP & AP | Surface |
| MCP | – | CA | CP/LP & AP | Surface |
| C4BP | DAA | CA | CP/LP | Fluid/surface |
| Factor H | DAA | CA | AP | Fluid/surface |
| FHL-1 | DAA | CA | AP | Fluid/surface |
| Factor I | Protease for degradation of C3b or C4b in presence of a cofactor | CP/LP & AP | Fluid (on surface only in conjunction with cofactor) | |
