Table 5.
Associations of age at diagnosis, and tumor TERT and ATRX status with overall survival in Group 4: IDH-wildtype glioblastomas.
| N (column %) | Age Median (range) | Percent deceased | Median survival years (95% CI) | Univariate analysis | Multivariate analysisc | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Hazard ratio | 95% CI | p value | Hazard ratio | 95% CI | p value | |||||
| All/Age (continuous) | 309 (100%) | 59 (24–89) | 81% | 1.2 (1.1–1.3) | 1.04 | (1.02–1.05) | <0.0001 | |||
|
| ||||||||||
| TERT-WT | 70 (23%) | 52 (24–85)a | 83% | 1.8 (1.2–2.2) | 0.67 | (0.5–0.91) | 0.01 | 0.90 | (0.65–1.25) | 0.53 |
| TERT-MUT | 239 (77%) | 62 (30–89)a | 80% | 1.1 (1.1–1.2) | Ref | Ref | ||||
|
| ||||||||||
| ATRX-WT | 298 (96%) | 60 (24–89)b | 81% | 1.2 (1.1–1.3) | Ref | Ref | ||||
| ATRX-MUT | 11 (4%) | 38 (33–61)b | 64% | 4.7 (2-NA) | 0.29 | (0.14–0.62) | 0.001 | 0.36 | (0.17–0.81) | 0.01 |
Patients with TERT-mutant tumors were older at diagnosis than patients with TERT-wildtype tumors (p<0.001).
Patients with ATRX-mutant tumors were younger at diagnosis than patients with ATRX-wildtype tumors (p<0.001).
Multivariate model includes TERT and ATRX status and was stratified by age (grouped as 24–53, 54–70, and 71–89) because age did not meet the Cox model’s proportionality assumptions.
In a model with ATRX alone, stratified by age at diagnosis, ATRX was significantly associated with survival better (hazard ratio: 0.35, 95% CI: 0.16–0.75, p value: 0.007)
Bolded values are statistically significant; 95% CI: 95% confidence interval; Ref: reference group.