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. 2017 May 16;4(3):ENEURO.0307-16.2017. doi: 10.1523/ENEURO.0307-16.2017

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Copyright © 2017 Stratton et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 3. — Adult human nerve- and skin-derived SCs are phenotypically indistinguishable in vitro and express proteins associated with precursor and immature stages of SC development. A–D, Representative immunocytochemical confocal images (46-year-old male) of adult human nerve (hN-SC)- and skin (hSk-SC)-derived SCs (NES⁺, green) and adult human skin-derived dermal fibroblasts (hSk-Fibro, FN1⁺, green) cultured in identical conditions. Immunocytochemistry revealed that SCs isolated from both human skin and nerve express several precursor and immature SC antigens (red, arrowheads), including (A) PAX3, (B) CDH19, (C) ETV5, and (D) SOX2. E, Quantification of the percentage of Hoechst⁺ cells expressing SOX2 in SC cultures. F, hSk-SCs also expressed the proliferative marker, ki67, in a similar percentage of cells to hN-SCs. Each dot represents the mean percentage within a patient culture (27-, 28-, 37-, and 46-year-old male) across three to four replicates (mean ± SEM, unpaired t test; scale bar, 25 μm).