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Schematic illustration of the HIV-1 gp41 protein and its peptide-based inhibitors. The gp41 numbering for HIV-1HXB2 is used. FP, fusion peptide; NHR, N-terminal heptad repeat; CHR, C-terminal heptad repeat; TM, transmembrane domain. The sequences corresponding to the CHR pocket-binding domain (PBD) are marked in red. The position and sequence of the M-T hook structure are marked in green.
