FIG 5.
Therapeutic efficacy of LP-19 in acutely SHIV-infected rhesus monkeys. (A to C) Starting from day 11 after virus inoculation, 12 SHIVSF162P3-infected monkeys were subcutaneously treated with normal saline (A), LP-19 (B), or T-20 (C) once daily for 4 weeks. The plasma viral loads of monkeys were measured at different time points by quantitative PCR. (D) Comparison of the viral load kinetics in monkeys treated with LP-19 and controls. A Mann-Whitney U test was performed to judge the significance of the difference during treatment (P = 0.0304 for LP-19 versus saline, P = 0.0315 for LP-19 versus T-20, and P = 1.000 for T-20 versus saline).