TABLE 1.
Survival times and rates of transmission of different CJD-MV inocula in TgHu mice
| Inoculum from human CJD | TgHu genotype | Survival time of PrPTSE-positive animals (days) (mean ± SD) | No. (%) PrPTSE-positive/no. animals tested | PrPTSE type |
|---|---|---|---|---|
| sCJD-MV1 | MM | 425 ± 71 | 12/15 (80) | 1 |
| VV | 542 ± 102 | 9/11 (82) | 1 | |
| MV | 501 ± 99 | 16/17 (94) | 1 | |
| sCJD-MV2 no. 1 | MM | 502 ± 88 | 16/16 (100) | 1 |
| VV | 229 ± 18 | 20/20 (100) | 2 | |
| MV | 519 ± 100 | 17/17 (100) | 1 | |
| sCJD-MV2 no. 2 | MM | 510 ± 62 | 13/16 (81) | 1 |
| VV | 258 ± 21 | 20/20 (100) | 2 | |
| MV | 541 ± 99 | 17/19 (89) | 1 | |
| CJD-MVAG | MM | −a | 0/14 (0) | |
| VV | 626 ± 29 | 4/18 (22) | AG | |
| MV | −a | 0/14° (0) |
a
These animals were observed for ≥500 days.