TABLE 2.
Survival times and rates of transmission of different CJD-MV inocula in bank voles
| Inoculum from human CJD-MV | Survival time of PrPTSE-positive/neuropathologically confirmed animals (days) (mean ± SD) | No. PrPTSE-positive or neuropathologically confirmed/no. animals tested (%) | PrPTSE typea |
|---|---|---|---|
| sCJD-MV1b | 179 ± 10 | 20/20 (100) | A |
| sCJD-MV2 | 544 ± 56 | 5/15 (33) | C |
| CJD-MVAG | 575 ± 120c | 25/27 (93) | Variable (n = 22) |
a
Type A and type C for voles infected with sCJD-MV1 and sCJD-MV2 as described by Pirisinu et al. (40). The variable type includes 7 animals showing a prevalent high pattern (H), with a mean survival time of 592 ± 162 days; 13 animals had a PrPTSE unglycosylated band migrating between type A and type C fragment size (I), with a survival time of 572 ± 98 days; 2 animals showed a prevalent low pattern (L), with survival times of 546 and 595 days.
b
Data from Nonno et al. (10).
c
Incomplete data for only 2 animals were previously reported by Zanusso et al. (12).