TABLE 1.
Lung pathology in PIV5/F- and PIV5/G-immunized animals after RSV challenge
| Vaccine | Challenge | Avg score |
||||
|---|---|---|---|---|---|---|
| Peribronchiolitis | Perivasculitis | Interstitial pneumonitis | Alveolitis | Mean | ||
| FI-RSV | RSV A2 | 2.67 | 3.00 | 2.00 | 2.00 | 2.42a |
| PIV5/F | RSV A2 | 2.33 | 2.00 | 0.67 | 1.00 | 1.50 |
| PIV5/G | RSV A2 | 2.33 | 1.67 | 1.00 | 1.00 | 1.50 |
| PBS | RSV A2 | 2.00 | 2.00 | 0.67 | 0.67 | 1.33 |
| PBS | PBS | 1.00 | 0.00 | 0.00 | 0.00 | 0.25 |
a
The histopathology score for FI-RSV was significantly higher than that observed for the PBS group challenged with RSV (P < 0.0001; t test).