TABLE 1.
Functional enrichment analysis of DE genes following EBOV or RESTV infection or LPS stimulationa
| Module | Ingenuity canonical pathway(s) | −log (P value) |
|---|---|---|
| Module 1 (588 transcripts, light blue) | Granulocyte adhesion and diapedesis | 1.87E + 01 |
| Role of hypercytokinemia/hyperchemokinemia in the pathogenesis of influenza | 1.73E + 01 | |
| Agranulocyte adhesion and diapedesis | 1.68E + 01 | |
| Role of cytokines in mediating communication between immune cells | 1.65E + 01 | |
| Communication between innate and adaptive immune cells | 1.54E + 01 | |
| Differential regulation of cytokine production in IECs by IL-17A and IL-17F | 1.32E + 01 | |
| Differential regulation of cytokine production in Mf and Th cells by IL-17A and IL-17F | 1.32E + 01 | |
| Role of pattern recognition receptors in recognition of bacteria and viruses | 1.31E + 01 | |
| Interferon signaling | 1.31E + 01 | |
| Activation of IRF by cytosolic pattern recognition receptors | 1.28E + 01 | |
| Module 2 (1,342 transcripts, dark blue) | Death receptor signaling | 1.20E + 01 |
| Antigen presentation pathway | 1.14E + 01 | |
| Type I diabetes mellitus signaling | 7.85E + 00 | |
| Cross talk between dendritic cells and natural killer cells | 7.58E + 00 | |
| Dendritic cell maturation | 7.51E + 00 | |
| TREM1 signaling | 7.45E + 00 | |
| NF-κB signaling | 6.70E + 00 | |
| Protein ubiquitination pathway | 6.61E + 00 | |
| GM-CSF signaling | 6.50E + 00 | |
| Role of macrophages, fibroblasts, and endothelial cells in rheumatoid arthritis | 6.26E + 00 | |
| Module 3 (938 transcripts, orange) | EIF2 signaling | 7.42E + 00 |
| Cell cycle control of chromosomal replication | 7.24E + 00 | |
| Breast cancer regulation by stathmin 1 | 7.08E + 00 | |
| Cell cycle: G2/M DNA damage checkpoint regulation | 6.31E + 00 | |
| Remodeling of epithelial adherens junctions | 6.26E + 00 | |
| Role of CHK proteins in cell cycle checkpoint control | 5.74E + 00 | |
| Mitotic roles of Polo-like kinase | 5.63E + 00 | |
| Gap junction signaling | 5.23E + 00 | |
| GDP-mannose biosynthesis | 4.40E + 00 | |
| Role of BRCA1 in DNA damage response | 4.12E + 00 | |
| Module 4 (805 transcripts, red) | CDP-diacylglycerol biosynthesis I | 3.87E + 00 |
| Phosphatidylglycerol biosynthesis II (nonplastidic) | 3.60E + 00 | |
| Gαi signaling | 3.15E + 00 | |
| Mismatch repair in eukaryotes | 2.78E + 00 | |
| Eicosanoid signaling | 2.26E + 00 | |
| G-protein-coupled receptor signaling | 2.22E + 00 | |
| cAMP-mediated signaling | 2.14E + 00 | |
| Leukotriene biosynthesis | 1.98E + 00 | |
| Antiproliferative role of TOB in T cell signaling | 1.98E + 00 | |
| The visual cycle | 1.90E + 00 |
a
The 10 most significantly enriched IPA canonical pathways for each gene expression module are shown. Colors refer to colors in Fig. 2C. Significance is considered a −log10 P value greater than 1.3 as determined by the Fisher exact test.