TABLE 2.
Functional enrichment analysis of DE genes following LPS stimulation of EBOV- or RESTV-infected cellsa
| Module | Ingenuity canonical pathway(s) | −log (P value) |
|---|---|---|
| 1,765 transcripts, red | Death receptor signaling | 1.58E + 01 |
| Type I diabetes mellitus signaling | 1.08E + 01 | |
| Induction of apoptosis by HIV1 | 1.07E + 01 | |
| TWEAK signaling | 1.03E + 01 | |
| Toll-like receptor signaling | 1.01E + 01 | |
| Role of pattern recognition receptors in recognition of bacteria and viruses | 1.00E + 01 | |
| TNFR1 signaling | 9.95E + 00 | |
| Unfolded protein response | 9.94E + 00 | |
| Role of PKR in interferon induction and antiviral response | 9.87E + 00 | |
| Interferon signaling | 9.76E + 00 | |
| Granulocyte adhesion and diapedesis | 2.22E + 01 | |
| 285 transcripts, orange | Agranulocyte adhesion and diapedesis | 2.02E + 01 |
| Role of hypercytokinemia/hyperchemokinemia in the pathogenesis of influenza | 1.94E + 01 | |
| Role of cytokines in mediating communication between immune cells | 1.91E + 01 | |
| Differential regulation of cytokine production in intestinal epithelial cells by IL-17A and IL-17F | 1.69E + 01 | |
| Differential regulation of cytokine production in macrophages and T helper cells by IL-17A and IL-17F | 1.66E + 01 | |
| Communication between innate and adaptive immune cells | 1.51E + 01 | |
| Cross talk between dendritic cells and natural killer cells | 1.01E + 01 | |
| Activation of IRF by cytosolic pattern recognition receptors | 9.60E + 00 | |
| Pathogenesis of multiple sclerosis | 9.55E + 00 | |
| Mismatch repair in eukaryotes | 7.79E + 00 | |
| 2261 transcripts, blue | Role of CHK proteins in cell cycle checkpoint control | 7.16E + 00 |
| Role of BRCA1 in DNA damage response | 6.86E + 00 | |
| Cell cycle control of chromosomal replication | 5.61E + 00 | |
| ATM signaling | 4.62E + 00 | |
| Estrogen-mediated S-phase entry | 4.46E + 00 | |
| Cell cycle: G1/S checkpoint regulation | 4.13E + 00 | |
| Antiproliferative role of TOB in T cell signaling | 4.11E + 00 | |
| Mitotic roles of Polo-like kinase | 3.95E + 00 | |
| DNA double-strand break repair by homologous recombination | 3.87E + 00 |
a
The 10 most significantly enriched IPA canonical pathways for each gene expression module are shown. Colors refer to colors in Fig. 9A. Significance is considered a −log10 P value greater than 1.3 as determined by the Fisher exact test.