Table 2.

Association analysis for MI and genome-wide significant DNAm sites

DNAm site	Chr	Position (bp)	Nearest gene	Relation to CpG island	Model 1		Model 2
					Effect ± SE	p	Effect ± SE	p
cg06642177	6	134,496,341	SGK1	CpG island	0.023 ± 0.004	4.33 × 10−8*	0.022 ± 0.004	7.47 × 10−7
cg07786668	16	73,092,391	ZFHX3	CpG island	0.018 ± 0.003	3.96 × 10−10*	0.016 ± 0.003	1.04 × 10−7*
cg17218495	19	11,071,743	SMARCA4	CpG island	0.015 ± 0.003	3.77 × 10−8*	0.015 ± 0.003	6.60 × 10−8*

The Effect and p values were calculated with a GLM, with the Effect values representing change in β value per change from control to case. The p values were corrected for genomic control

Chr chromosome

*Genome-wide significance (p < 1.43 × 10⁻⁷)