Table 3.
Association analysis for SNPs and DNAm sites located in ZFHX3 and SMARCA4 for the control group
| SNP | Chromosome | Position (bp) | Strand | Allele (minor/major) | MAF (%) | DNAm site | Effect ± SE | p |
|---|---|---|---|---|---|---|---|---|
| ZFHX3 | ||||||||
| rs7193343 | 16 | 73,029,160 | + | C/T | 40.4 | cg07786668 | −0.0011 ± 0.0011 | 0.307 |
| cg00614832 | 0.0004 ± 0.0013 | 0.755 | ||||||
| rs2106261 | 16 | 73,051,620 | + | T/C | 33.1 | cg07786668 | −0.0016 ± 0.0011 | 0.176 |
| cg00614832 | 0.0004 ± 0.0014 | 0.774 | ||||||
| rs879324 | 16 | 73,068,678 | + | A/G | 38.3 | cg07786668 | −0.0015 ± 0.0011 | 0.186 |
| cg00614832 | 0.0005 ± 0.0014 | 0.718 | ||||||
| SMARCA4 | ||||||||
| rs3786725a | 19 | 11,166,827 | + | A/G | 11.2 | cg17218495 | 0.0008 ± 0.0011 | 0.461 |
The Effect and p values were calculated with a GLM. The Effect value represents the change in β-value per minor allele copy for the SNP
aThis SNP is in linkage disequilibrium with rs1122608 in SMARCA4 (r 2 = 0.956 based on Asian samples of the 1000 Genomes Project phase I)