Table 3.

Measured accuracies of eight in silico predictors as benchmarked against seven different variant reference datasets. Measured accuracies are calculated as the areas under the respective ROC curves (AUCs) and Matthews correlation coefficients (MCCs). See Additional file 1: Figure S4 for the ROC curve graphs

	ClinvarHC		Humsavar		Swissvar		Varibench		TP53-TA		BRCA1-DMS		UniFun
	AUC	MCC	AUC	MCC	AUC	MCC	AUC	MCC	AUC	MCC	AUC	MCC	AUC	MCC
GERP++	0.863	0.587	0.777	0.469	0.677	0.286	0.571	0.15	0.719	0.283	0.544	0.069	0.538	0.04
fitCons	0.641	0.3	0.533	0.033	0.564	0.008	0.651	0.024	0.557	0	0.559	0	0.515	0.033
SIFT	0.848	0.489	0.841	0.543	0.698	0.289	0.651	0.228	0.835	0.484	0.653	0.199	0.631	0.184
PolyPhen	0.827	0.447	0.831	0.541	0.699	0.301	0.672	0.256	0.859	0.469	0.596	0.088	0.623	0.168
CADD	0.939	0.731	0.851	0.57	0.73	0.331	0.663	0.25	0.869	0.418	0.556	0.032	0.589	0.119
Condel	0.879	0.51	0.911	0.664	0.728	0.333	0.86	0.57	0.883	0.074	0.747	0.172	0.614	0.098
REVEL	0.945	0.68	0.968	0.83	0.792	0.462	0.89	0.59	0.907	0.465	0.737	0.088	0.63	0.148
fathmm	0.787	0.288	0.902	0.538	0.701	0.253	0.936	0.509	0.53	0	0.621	0	0.531	0.02