Table 2.
Univariate and multivariate Cox regression analyses of disease-free survival of 307 patients with primary thymoma
| Variable | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
| Age (years) | ||||||
| ≤60 | ||||||
| >60 | 0.733 | 0.345–1.558 | 0.420 | |||
| Sex | ||||||
| Female | ||||||
| Male | 1.175 | 0.680–2.028 | 0.563 | |||
| Tumor size (cm) | 1.017 | 0.913–1.132 | 0.762 | |||
| Myasthenia gravis | ||||||
| Yes | ||||||
| No | 1.254 | 0.610–2.580 | 0.538 | |||
| WHO histological classification | ||||||
| A + AB | ||||||
| B1 | 2.513 | 0.844–7.481 | 0.098 | 1.530 | 0.492–4.759 | 0.463 |
| B2 | 6.831 | 2.810–16.604 | <0.001 | 2.855 | 1.070–7.621 | 0.036 |
| B3 | 7.999 | 3.032–21.108 | <0.001 | 2.404 | 0.809–7.141 | 0.114 |
| Masaoka stage | ||||||
| I | ||||||
| II | 2.284 | 0.669–7.801 | 0.188 | 1.211 | 0.326–4.501 | 0.775 |
| III | 12.624 | 3.800–41.943 | <0.001 | 4.935 | 1.289–18.894 | 0.020 |
| IVa | 26.872 | 7.102–101.680 | <0.001 | 13.809 | 3.230–59.043 | <0.001 |
| Surgical approach | ||||||
| Transthoracic | ||||||
| Transsternal | 0.803 | 0.421–1.532 | 0.506 | |||
| VATS | 1.304 | 0.635–2.676 | 0.470 | |||
| Postoperative radiotherapy | ||||||
| Yes | ||||||
| No | 2.212 | 1.214–4.032 | 0.010 | 1.887 | 0.932–3.823 | 0.078 |
CI confidence interval, HR hazard ratio, WHO World Health Organization, VATS video-assisted thoracoscopic surgery