Table 3.
Univariate and multivariate Cox regression analyses of overall survival of 307 patients with primary thymoma
| Variable | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
| Age (years) | ||||||
| ≤60 | ||||||
| >60 | 2.290 | 1.171–4.481 | 0.016 | 1.801 | 0.850–3.818 | 0.125 |
| Sex | ||||||
| Female | ||||||
| Male | 1.187 | 0.627–2.245 | 0.599 | |||
| Tumor size (cm) | 1.114 | 0.989–1.255 | 0.075 | |||
| Myasthenia gravis | ||||||
| Yes | ||||||
| No | 1.554 | 0.647–3.730 | 0.324 | |||
| WHO histological classification | ||||||
| A + AB | ||||||
| B1 | 4.904 | 1.510–15.930 | 0.008 | 4.455 | 1.329–14.936 | 0.016 |
| B2 | 3.605 | 1.147−11.333 | 0.028 | 2.860 | 0.823–9.940 | 0.098 |
| B3 | 11.819 | 3.884–35.964 | <0.001 | 6.372 | 1.837–22.103 | 0.004 |
| Masaoka stage | ||||||
| I | ||||||
| II | 1.272 | 0.418–3.877 | 0.672 | 0.930 | 0.291–2.966 | 0.902 |
| III | 3.468 | 1.116–10.777 | 0.032 | 1.812 | 0.531–6.184 | 0.342 |
| IVa | 11.705 | 3.495–39.203 | <0.001 | 4.215 | 1.010–17.593 | 0.048 |
| Surgical approach | ||||||
| Transthoracic | ||||||
| Transsternal | 1.001 | 0.485–2.063 | 0.998 | |||
| VATS | 1.455 | 0.597–3.547 | 0.409 | |||
| Postoperative radiotherapy | ||||||
| Yes | ||||||
| No | 1.516 | 0.775–2.966 | 0.224 | |||
CI confidence interval, HR hazard ratio, WHO World Health Organization, VATS video-assisted thoracoscopic surgery