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. 2017 May 15;18:382. doi: 10.1186/s12864-017-3775-6

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Maximum Relevance Minimum Redundancy (MRMR) expression network of immunity related genes responding to CHIKV infection in midguts of SM and PM fed mosquitoes. The arrows indicate that FREP14 was predicted as the most central immunity gene in CHIKV infected midguts of SM and PM fed mosquitoes when compared to non-infected midguts demonstrating its importance in the innate immune response to CHIKV infection of the mosquito midgut. The centrality score indicated is based on a degree centrality measure, showing how central the gene is to the given network. Differences in the centrality scores underline their role in differentially modulating the cross-talk of immunity genes depending on SM or PM ingestion. Genes used for the network analysis were: FREP14 (AAEL007942), FREP10 (AAEL008646), GNBP4 (AAEL009178), PGRP1 (AAEL009474), FREP37 (AAEL011007), ML26B (AAEL013835), TEP20 (AAEL001794), CECG (AAEL015515), TPX4 (AAEL002309), ATT (AAEL003389), LYSC11 (AAEL003723), DEFC (AAEL003832), DEFD (AAEL003857), FREP9 (AAEL004156), GAM (AAEL004522), CECN (AAEL000621), and CECA (AAEL000627)