Table 1. Antibacterial activity of the compounds against gram-positive bacterial strains. If required, the highest concentration tested was 512 μg mL–1. “ia” (inactive) designates no activity of the compound up to this highest concentration.
| Compound | Structure | MIC |
|||||
|
B. subtilis
|
S. aureus DSM 20231 |
S. aureus ATCC43300 (MRSA) |
|||||
| μg mL–1 | μM | μg mL–1 | μM | μg mL–1 | μM | ||
| 1a (ref. 33) |
|
2 | 1.4 | 2 | 1.4 | 2 | 1.4 |
| 1b (ref. 33) |
|
32 | 21 | 4 | 2.7 | 6 | 4 |
| 7d |
|
ia | ia | ia | |||
| 9a |
|
4 | 3 | 2 | 1.5 | 2 | 1.5 |
| 9b |
|
4 | 2.9 | 4 | 2.9 | 2 | 1.5 |
| 5a |
|
ia | ia | ia | |||
| 7a |
|
ia | ia | ia | |||
| 7b |
|
ia | ia | ia | |||
| 9c′ |
|
4 | 3.3 | 2 | 1.6 | 2 | 1.6 |
| 8 (ref. 33) |
|
ia | ia | ia | |||
| 5b |
|
ia | ia | ia | |||
| 7c |
|
ia | ia | ia | |||
| 10 |
|
ia | ia | ia | |||
| Amoxicillin 33 | 3 | 8.2 | 2 | 5.5 | 48 | 131 | |
| Norfloxacin 33 | 1 | 3.1 | 0.5 | 1.6 | 0.5 | 1.6 | |