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STI1 signaling mediated by the cellular prion protein (PrPC). (Right) PrPC binding to extracellular STI1 induces neuroprotective and neuro- differentiation through Ca2+ influx via α7-nAChR. (Left) Aβ oligomers transmit toxic signaling events through PrPC. STI1 inhibits Aβ oligomer binding to PrPC and/or activate protective signaling events.
