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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Adv Chronic Kidney Dis. 2017 May;24(3):176–182. doi: 10.1053/j.ackd.2017.03.002

Figure 1.

Figure 1

Diagram of the biokinetic model for gadolinium (Gd) as delivered from Gd-based contrast agents (GBCAs). The model is adapted from Taylor and Leggett (40) and the CONRAD model for DTPA for decorporation of radionuclides (41). Compartments labeled with an asterisk are permeable to free ligand and intact GBCA, and the dashed arrows were reduced by the simulated fraction of normal kidney function. GBCA compartments also allow dissociation of the intact Gd-ligand complex and association between Gd and ligand.