Figure 3.
Relationship between Pressure-Rate Product (PRP, mean arterial pressure X heart rate) and myocardial blood flow (MBF). MBF and DP were measured under basal conditions, hexamethonium and norepinephrine (0.5–5.0 µg/kg/min iv; in the presence of hexamethonium). In Kv 1.3−/− mice (n=15) MBF was significantly lower compared to WT mice (n=14) at any level of the PRP.