Chart 6. Measures for secondary prevention of adverse reactions to intravenous immunoglobulin.
| Slower rate of infusion in patients with prior reaction |
| Pre-medication with analgesics and/or nonsteroidal anti-inflammatory drugs, H1 (and anti H2) antihistamines, and corticosteroids |
| Pre-hydration with 0.9% saline solution |
| Switch product or consider subcutaneous Ig in case of major reactions with no response to symptomatic drugs |
Ig: immunoglobulin.