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. 2016 Apr 19;2:2055217316641704. doi: 10.1177/2055217316641704

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© The Author(s) 2016

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — LINGO-1 blockade reduced morbidity and mortality of myelin oligodendrocyte glycoprotein experimental autoimmune encephalomyelitis (MOG-EAE) mice. (a) The percentage of MOG-EAE mice reaching complete hindlimb paralysis (grade 3 disease severity) exposed to anti-LINGO-1 monoclonal antibody (mAb) 3B5 or control antibody (ctrl Ab). (b) The percentage survival of MOG-EAE mice exposed to mAb 3B5 or ctrl Ab. Data shown as mean ± standard deviation (SD). Day 16 p values were determined using a log-rank test. LINGO-1: leucine-rich repeat and immunoglobulin-like domain-containing Nogo receptor-interacting protein 1.