TABLE 4.

Forced vital capacity and diffusion capacity change over time for interstitial lung disease subjects with heterozygous TERT, TERC, RTEL1 or PARN mutations

PFT parameter	Group	N	Mean number of measurements	Mean follow-up time years	Mean change per year	p-value
FVC L	All	71	3.89	2.42	−0.30
	TERT	46	3.76	2.16	−0.30	NS
	TERC	6	4.67	2.23	−0.26
	RTEL1	10	3.70	2.94	−0.35
	PARN	9	4.22	3.30	−0.27
FVC % predicted	All	71	3.83	2.40	−7.40
	TERT	46	3.67	2.13	−7.48	NS
	TERC	6	4.67	2.23	−6.65
	RTEL1	10	3.70	2.94	−7.59
	PARN	9	4.22	3.30	−7.87
DLCO mL·min−1·mmHg−1	All	67	3.39	2.30	−1.73
	TERT	44	3.25	2.04	−1.73	NS
	TERC	5	4.00	2.26	−0.81
	RTEL1	9	3.11	2.62	−2.11
	PARN	9	4.00	3.30	−1.80
DLCO % predicted	All	69	3.33	2.23	−6.26
	TERT	46	3.15	1.94	−6.35	NS
	TERC	5	4.00	2.26	−2.53
	RTEL1	9	3.11	2.62	−5.71
	PARN	9	4.11	3.30	−7.53

NS: nonsignificant; PFT: pulmonary function test; FVC: forced vital capacity; DLCO: diffusion capacity of the lung for carbon monoxide.