TABLE 5.
Cumulative events and time to death or lung transplantation for interstitial lung disease subjects with TERT, TERC, RTEL1 or PARN mutations
| Subjects n | Death | Transplant | Death or transplant | Time to death or transplant years | |||
|---|---|---|---|---|---|---|---|
|
| |||||||
| n | Events n | Median (95% CI) | |||||
| Total | 115 | 59 (51) | 34 (30) | 93 (81) | 106 | 88 | 2.87 (2.40–3.80) |
| TERT | 75 | 36 (48) | 27 (36) | 63 (84) | 70 | 61 | 2.71 (2.36–3.6) |
| TERC | 7 | 3 (43) | 2 (29) | 5 (71) | 7 | 5 | 2.54 (1.92–NA) |
| RTEL1 | 14 | 8 (57) | 2 (14) | 10 (71) | 13 | 9 | 2.87 (2.30–NA) |
| PARN | 19 | 12 (63) | 3 (16) | 15 (79) | 16 | 13 | 5.73 (2.55–NA) |
| Multidisciplinary diagnosis | 77 | ||||||
| IPF | 35 | 15 (43) | 14 (40) | 29 (83) | 35 | 29 | 2.75 (1.64–4.61) |
| Non-IPF | 42 | 18 (43) | 15 (36) | 33 (79) | 42 | 33 | 3.11 (2.56–4.82) |
Data are presented as n (%), unless otherwise stated. IPF: idiopathic pulmonary fibrosis.