TABLE 6.

Analysis of transplant-free survival for interstitial lung disease subjects with TERT, TERC, RTEL1 or PARN mutations

	N	Univariable analysis		Multivariable analysis (n=36)
		Hazard ratio (95% CI)	p-value	Hazard ratio (95% CI)	p-value
Age at diagnosis	106	1.02 (1–1.04)	0.048	1.05 (0.99–1.12)	0.096
Male	106	1.6 (1.04–2.44)	0.031	0.95 (0.28–3.23)	0.93
FVC % predicted#,¶	62	0.65 (0.53–0.79)	<0.0001	0.49 (0.3–0.79)	0.0035
DLCO % predicted#,¶	55	0.81 (0.64–1.02)	0.071	1.32 (0.79–2.21)	0.28
Gene
TERT		Ref		Ref
TERC	106	0.79 (0.32–1.98)	0.61	0.67 (0.06–7.56)	0.74
RTEL1	106	0.75 (0.37–1.51)	0.42	0.58 (0.11–2.96)	0.51
PARN	106	0.72 (0.39–1.31)	0.28	0.26 (0.06–1.19)	0.083
Log (T/S) telomere length	80	0.76 (0.3–1.93)	0.57	6.18 (0.91–42.13)	0.063
IPF versus non-IPF	77	1.34 (0.81–2.23)	0.25	0.46 (0.18–1.22)	0.12

FVC: forced vital capacity; DLCO: diffusion capacity of the lung for carbon monoxide; IPF: idiopathic pulmonary fibrosis.

^#: hazard ratios are given per 10 percentage-points difference in % predicted FVC and DLCO.

^¶: analysis restricted to patients with pulmonary function test within 1 year of diagnosis.