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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Metab Eng. 2016 Oct 19;38:446–463. doi: 10.1016/j.ymben.2016.10.009

Figure 12. Effect of (A) NADPH and (B) coenzyme A concentrations on specific carbon fixation rate for metabolic engineering applications of 3HP/4HB cycle at optimum enzyme ratios predicted by model.

Figure 12

Dotted lines indicate the baseline NADPH and CoA concentrations at which enzymes ratios were optimized. *Sharp corners in curves for autotrophic succinate pathway represent points above which buildup of pathway intermediates prevents reaching steady-state. ^Sharp corner in heterotrophic succinate pathway represents the point below which buildup of pathway intermediates prevents reaching steady-state.