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. 2017 May 1;9(5):1229–1240. doi: 10.1093/gbe/evx085

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© The Author 2017. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Fig. 2. — —Experimental evolution of S. cerevisiae reveals that mutational genome hotspots are traps for duplicates. We identified mutations in the coding region and 600-nucleotide genome regions upstream genes in S. cerevisiae and calculated the nonsynonymous nucleotide substitutions (d_N) between S. cerevisiae and its close phylogenetic relative S. paradoxus for the six genes surrounding that gene with a SNP in its promoter. (a) Genes that have fixed a SNP in the promoter regions (black columns) in each of the five experimentally evolving line (MA1–MA5) exhibit significantly higher (* indicates P < 0.01; ** indicates P < 0.001) d_N than those without SNPs (white boxes). (b) Genome regions that contain duplicates (GRDs) exhibit more SNPs than in the promoter (black columns) fixed during the evolution experiment of each line (MA1 to MA5) (* indicates P < 0.01; ** indicates P < 0.001) than genome regions that do not contain duplicates (GRSs) (white columns).