Table 1.
Foot-and-Mouth Disease Viruses (FMDV) Used in the Present Study
| Name | Origin | Reference |
|---|---|---|
| FMDV CS-8c1 | Biological clone from natural isolate C1-Sta. Pau-Spain | Sobrino et al. 1983 |
| pMT28 | Molecular clone derived from CS-8c1 | Toja et al. 1999 |
| García-Arriaza et al. 2005 | ||
| FMDV MARLS | A monoclonal antibody-resistant mutant derived from FMDV C-S8c1 passaged 213 times in BHK-21 cells | Charpentier et al. 1996 |
| FMDV-RP | A ribavirin-resistant mutant of FMDV MARLSa | Sierra et al. 2007 |
a
FMDV MARLS displays high replicative fitness relative to FMDV C-S8c1, and this was the reason to use it as the parental FMDV population to derive the ribavirin-resistant mutant FMDV-RP.