Table 3.

Clinical and laboratory data of clinically isolated syndrome (CIS) patients using $\kappa$ index cut-off of 10.62. Subgroup 1: patients with $\kappa$ index > 10.62; subgroup 2: patients with $\kappa$ index < 10.62.

	Subgroup 1	Subgroup 2	p Value
Patients (n)	49	28	–
Gender (females %)	41 (83.7)	19 (67.9)	–
Age (mean (95% CI))	34.1 (31.3–36.9)	37.4 (32.9–41.8)	0.186
OCGB (+/−)	44/5	4/24	<0.0001
IgG index (>0.56/<0.56)	46/3	3/25	<0.0001
≥3 BCT (%)	30 (61.2)	6 (21.4)	0.008
Fulfilled MRI and OCGB criteria (yes/no)	29/17	3/17	<0.0001
Conversion to MS (%)	35 (71.4)	3 (10.7)	<0.0001

BTC: Barkhof-Tintoré criteria; CI: confidence interval; IgG: immunoglobulin G; MRI: magnetic resonance imaging; MS: multiple sclerosis; OGCB: oligoclonal IgG band.