Table 1.
Anti-MOG+ patients – clinical course, MRI and therapy.
| No. | Diagnosis | Age at onset | Gender | Disease duration | VFS | EDSS | Relapse prevention therapy | Brain MRI lesions | Optic nerve + | MRI spinal cord |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NMO | 46 | M | 8 | 5 | 10 | AZA for 1 year prior to death | Subcortical | Unilateral | C5–D7 cord atrophy |
| 2 | NMO | 24 | F | 6 | 2 | 1.5 | AZA | Normal | Bilateral & chiasm | D1–D6 |
| 3 | RTM | 6 | M | 4 | 0 | 2 | MMF | Periaqueductal | Normal | D1–D8 |
| 4 | RTM | 21 | F | 2 | 0 | 2 | IFN (6 months), MMF | Subcortical | Normal | C4–D7 |
| 5 | RTM | 5 | M | 14 | 0 | 1 | NT | Brainstem & thalamus | Normal | D7–conus |
| 6 | ATM | 31 | M | 8 | 0 | 0 | NT | Normal | Normal | D1–D6 |
| 7 | ATM | 55 | M | 6 | 0 | 0 | NT | Normal | Normal | D5–D7 |
| 8 | ATM | 26 | M | 5 | 0 | 1 | NT | Brainstem | Normal | C4–D7 |
| 9 | ATM | 26 | M | 4 | 0 | 0 | NT | Normal | Normal | D4–D9 |
| 10 | ATM | 22 | M | 3 | 0 | 0 | NT | Normal | Normal | C3–conus |
| 11 | ATM | 37 | M | 2 | 0 | 0 | NT | Normal | Normal | D1–D6 |
| 12 | ATM | 42 | M | 1 | 0 | 1 | NT | Normal | Normal | D6–D9 |
| 13 | ATM | 16 | F | 1 | 0 | 1 | NT | Subcortical | Normal | C2–T6 |
| 14 | ATM | 14 | M | 3 | 0 | 0 | NT | Thalamus, brainstem, subcortical | Normal | C6–D8 |
| 15 | RON | 14 | M | 16 | 4 | 2 | NT | Normal | Unilateral | Normal |
| 16 | RON | 28 | M | 8 | 2 | 1 | MMF | Normal | Normal | Normal |
| 17 | RON | 28 | F | 4 | 2 | 1 | NT except steroids during relapse | Normal | Normal | Normal |
| 18 | RON | 16 | M | 4 | 1 | 1 | Stopped AZT after 1 year, no recurrence | Normal | Unilateral | Normal |
| 19 | RON | 32 | F | 12 | 2 | 1 | Stopped AZT after 1 year, no recurrence | Normal | Unilateral | Normal |
| 20 | RON | 19 | F | 10 | 1 | 0 | NT except steroids during relapse | Normal | Unilateral | Normal |
| 21 | RON | 5 | F | 8 | 2 | 1 | MMF | Normal | Normal | Normal |
| 22 | RON | 28 | M | 2 | 2 | 1 | MMF | Normal | Bilateral optic nerve & chiasm | Normal |
| 23 | RON | 7 | F | 4 | 1 | 0 | MMF | Subcortical | Normal | Normal |
| 24 | RON | 41 | M | 3 | 2 | 1 | MMF | Normal | Unilateral | Normal |
| 25 | RON | 20 | F | 4 | 0 | 0 | NT except steroids during relapse | Thalami, brainstem, subcortical | Normal | Normal |
anti-MOG+: autoantibodies against myelin oligodendrocyte glycoprotein; MRI: magnetic resonance imaging; NMO: neuromyelitis optica; RTM: recurrent transverse myelitis; ATM: acute transverse myelitis; RON: recurrent optic neuritis; AZA: azathioprine; MMF: mycophenolate mofetil; VFS: visual functional score; EDSS: Expanded Disability Status Scale; NT: not treated; NA: not applicable.